Endocrine Abstracts

Background and objectives: Obesity is associated with a relatively high prevalence of anaemia and iron deficiency compared to normal weight individuals; the cause is unknown. We aimed to determine the prevalence of iron deficiency and anaemia in a severely obese cohort of bariatric surgery candidates, and to explore underlying associations with markers of nutrition and inflammation.Methods: In a retrospective review of 703 consecutive patients presenting...

Background: The National Paediatric Diabetes Audit has identified inequalities in diabetes care. Children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM) from both ethnic minority backgrounds and deprived areas are more likely to have reduced access to diabetes technologies and a higher HbA1c. In our service there was an inconsistent approach to the initiation of Continuous Glucose Monitoring (CGM) and use of insulin pumps. The introduction of a st...

Background and objectives: Vitamin D deficiency and insufficiency is common in obese individuals. We aimed to determine the prevalence of vitamin D insufficiency within a cohort of severely obese individuals, exploring potential underlying associations.Methods: In a retrospective analysis of 703 patients sequentially presenting for bariatric surgery assessment, 663 had complete demographic, anthropometric, and haematological measures (vitamin D, folate, ...

We present the case of a 62 year old gentleman who was diagnosed with Acromegaly in 1998.He commenced testosterone replacement therapy in the form of Sustanon every three weeks in October 2000 following a testosterone level of 6.6 nmol/l.PSA levels during treatment with Sustanon were: 01/03/01–5.1μg/l.06/04/01–4.9 μg/l at which point he was referred for a urological opinion.<p class="a...

Background: Testosterone replacement therapy is available in a variety of preparations. Nebido, a long acting testosterone undecanoate injection offered at 3 monthly intervals, has recently become available thus reducing the need for frequent injections.Aim: To investigate the efficacy and safety of Nebido.Patients and methods: Eighteen patients aged between 22–77 years (median 44.5 years) with primary or secondary hypogonadis...

Pancreatic islets are susceptible to hypoxia during isolation, culture, and transplantation. An intervention that protects against hypoxia while preserving β-cell function will improve islet quality. Adrenaline suppresses insulin secretion and oxygen consumption in pancreatic islets. These findings suggest that adrenergic action creates metabolic quiescence in β-cells. Our objective was to determine whether adrenaline is protective during hypoxic culture in an insuli...

Aim: In normal men testosterone levels fall with age. We wished to assess the efficacy and safety of Nebido in men over the age of 60 years in order to assess dose frequency and other potential complications.Subjects and methods: Ten men over 60 years of age (range 60–77 median 64) with primary or secondary hypogonadism were treated with Nebido 1000 mg i.m. Each was given a loading dose of two injections 6 weeks apart (our normal protocol for all pa...

Pituitary tumor transforming gene (PTTG) is a multifunctional oncogene implicated in the pathogenesis of pituitary and thyroid tumours. In breast cancer, PTTG expression is a prognostic marker for lymph node invasion and tumour recurrence. PTTG expression is regulated in vitro and in vivo by oestrogen treatment. PTTG binding factor (PBF) is also a transforming gene, and was isolated due to its functional interaction with PTTG. In the current study, we examined PB...

Differentiation between non functioning pituitary macroadenomas (NFPA) and prolactinomas may be difficult as hyperprolactinaemia can also be present at diagnosis in NFPA cases due to pituitary stalk compression (disconnection hyperprolactinaemia). Some authors suggested that prolactin >2,000 mIU/l is almost diagnostic of a prolactinoma, while others use a higher cut-off of >5000 mIU/l. Our aim was to identify the level of prolactin above which a prolactinoma was more l...

Studies on the probability of recurrence of surgically treated but radiotherapy (RT) naïve non-functioning pituitary adenomas (NFPA) are inconsistent and selective as cases deemed to be at high risk of recurrence were prophylactically irradiated. We traditionally used very low rate of post-operative RT leaving us with a largely unselected cohort.We identified 223 surgically resected, histology-proven NFPA cases. Only 9% received post-operative RT an...